Indianapolis, IN (Sports Network) - Donald Brown ran for 161 yards, including an 80-yard score to put the game away late in the fourth quarter, as the Indianapolis Colts earned their first win of the season with a 27-13 triumph over the Tennessee Titans.
Reggie Wayne caught three balls for 33 yards and a score for Indianapolis (1-13), which won its first game without Peyton Manning under center since December 14, 1997 when Jim Harbaugh led the Colts to a 41-0 win over the Miami Dolphins.
Dan Orlovsky threw for 82 yards and a score on 11-of-17 passing, and middle linebacker Pat Angerer had an interception and a forced fumble.
Chris Johnson ran for 55 yards and caught eight passes for 54 yards for the Titans (7-7), who have lost two straight.
Matt Hasselbeck tried gutting it out on a bum ankle and threw for 223 yards with two interceptions. Jake Locker came on in the fourth quarter and threw for 108 yards and a touchdown on 11-of-16 passing.
The Sports Network